Best way to convert RGB images to CMYK to preserve original colors.

Hello all. So i just downloaded the plug in to allow me to convert RGB images to CMYK in GIMP. But i have many questions about this. WHich choices are best to choose when doing this? What file type should i save it as to get the best quality? Some of the images i'll change will be used on our website, and some will be used to make 4 color card flers (postcards). Please help.

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